The piston is usually pushed by the release of a compressed metal spring, although devices being studied may use piezoelectric effects and other novel technologies to pressurize the liquid in the chamber.
Gas-powered and hydraulically powered devices may involve hoses that carry compressed gas or hydraulic fluid from separate cylinders of gas, electric air pumps, foot-pedal pumps, or other components to reduce the size and weight of the hand-held part of the system and to allow faster and less-tiring methods to perform numerous consecutive vaccinations.
However, the World Health Organization no longer recommends jet injectors for vaccination due to risks of disease transmission.
The term "hypospray", although better known from its usage in the 1960s television show Star Trek, is attested in the medical literature as early as 1956.
Researchers developed a new jet injection design by combining the drug reservoir, plunger and nozzle into a single-use disposable cartridge.
[5] Since the jet injector breaks the barrier of the skin, there is a risk of blood and biological material being transferred from one user to the next.
Samir Mitragrotri visually captured splash-back after discharging a multi-use nozzle jet injector using high-speed microcinematography.
[6] The CDC has acknowledged that the most widely used jet injector in the world, the Ped-O-Jet, sucked fluid back into the gun.
The World Health Organization no longer recommends jet injectors for vaccination due to risks of disease transmission.
An experiment using mice, published in 1985, showed that jet injectors would frequently transmit the viral infection lactate dehydrogenase elevating virus (LDV) from one mouse to another.
[14] From 1984 to 1985, a weight-loss clinic in Los Angeles administered human chorionic gonadotropin (hCG) with a Med-E-Jet injector.