For certain substances, administration via an ID route can result in a faster systemic uptake compared with subcutaneous injections,[1] leading to a stronger immune response to vaccinations, immunology[clarification needed] and novel cancer treatments, and faster drug uptake.

[2] Additionally, since administration is closer to the surface of the skin, the body's reaction to substances is more easily visible.

Common injection sites include the inner surface of the forearm, the upper back, deltoid, thigh, and under the shoulder blade.

Various microneedle technology researchers worldwide develop new devices and therapies to overcome typical usability issues associated with the traditional Mantoux procedure.

[4] Immune reaction tests sometimes use a set of non-hollow needles for scarification, shallowly abrading the skin.