Despite its odd-numbered Florida Department of Transportation designation, SR 579 is signed east–west.

Fletcher Avenue between Nebraska Avenue and I-75 was later redesignated State Road 582A (and a spur, 50th Street between Fletcher Avenue and Fowler Avenue adjacent to University of South Florida, became State Road 582B) while Morris Bridge Road was transitioned to County Road 579.

Locally known as Biscayne Drive and Southwest 288th Street, the historic State Road 579 was a 3.2-mile (5.1 km) east–west street connecting South Dixie Highway (U.S. Route 1/SR 5) in Homestead to the west (primary) gate of Homestead Air Force Base.

[4][5][6][7] While Homestead AFB was downgraded to a smaller Homestead Air Reserve Base after its destruction by Hurricane Andrew in 1993, Coral Castle, a tourist attraction at the western end of historic SR 579, has remained essentially unchanged since the FDOT signs were removed from Biscayne Drive in the late 1960s.

The predominantly rural nature of the area on both sides of the street in the 1950s and 1960s has been gradually giving way to urbanization since the 1980s and the trend appears to be accelerating throughout the former Homestead AFB property and further south in Miami-Dade County, particularly along the nearby Homestead Extension of Florida's Turnpike.