The route passes through the lower and central portions of Bucks County, serving Bristol, Levittown, Langhorne, Newtown, and Buckingham.

PA 413 turns northwest at an intersection with Otter Street and passes under Amtrak's Northeast Corridor railroad line before it reaches a junction with US 13.

The route fully enters Bristol Township again and continues through residential areas with a few businesses as a five-lane road with a center left-turn lane, passing to the west of the Lower Bucks Campus of Bucks County Community College.

[2][3] Following this, the route reverts to a five-lane road with a center left-turn lane and runs through commercial areas.

PA 413 becomes a four-lane divided highway before it passes under the Pennsylvania Turnpike (I-95) and narrows into a two-lane undivided road.

The road gains a center left-turn lane and passes businesses as it forms the western border of the planned residential community of Levittown.

A block later, the route intersects the northern terminus of PA 513 and heads north on Bellevue Avenue.

The route crosses PA 213 in the center of Langhorne and becomes North Pine Street, passing near some businesses before heading past more homes.

PA 413 crosses back into Middletown Township, where the name changes to Newtown Langhorne Road, and passes under Norfolk Southern's Morrisville Line and an abandoned railroad line before heading into wooded areas along the eastern bank of the Neshaminy Creek and curving northwest.

The roadway passes over an access road to Council Rock High School North before it heads to the east of Tyler State Park, curving to the northwest.

At the entrance to the park, PA 413/PA 532 turn northeast to remain on the Newtown Bypass while Swamp Road heads to the northwest.

The route runs through more rural areas with some development, crossing PA 232 in the community of Penns Park.

The road continues northwest through agricultural and wooded areas, passing to the north of the residential community of Buckingham Springs.

[2][3] Past US 202, PA 413 becomes a two-lane undivided road again, continuing northwest through wooded areas with some fields and homes.

The road passes through the community of Mechanicsville and runs through more rural areas with some suburban residential subdivisions.

The route heads into Plumstead Township after the intersection with Landisville Road and Ridgeview Drive and continues to the community of Gardenville, where it crosses Point Pleasant Pike.

A short distance later, the route turns west onto Deep Run Road and reaches its northern terminus at an intersection with PA 611.

The Durham Road split into several branches in upper Bucks County, connecting to Bethlehem and Easton.