From this point, the road runs near some residential areas prior to passing under the Garden State Parkway and crossing the marshy Patcong Creek into Egg Harbor Township.

After this intersection, the road crosses the English Creek and runs through more forested areas with some development as it comes to the CR 615 junction.

The route continues into Hamilton Township, where the road turns northeast into increasing areas of forested residential development.

The road continues northwest past more forests and development, coming to an intersection with US 40 and CR 617 in the community of Mays Landing.

[1][2] At this point, CR 559 forms a concurrency with US 40 and heads west through areas of homes and businesses on Main Street, coming to an intersection with Route 50.

The route leaves Mays Landing as it turns west onto Weymouth Road, with CR 616 heading south along Lenape Street.

The road continues northwest through the forests, with occasional residences, prior to turning north and then northeast as it meets US 322 (Black Horse Pike) at a modified traffic circle.

The road travels through the following municipalities (from South to North): Major intersections The entire route is in Atlantic County.