CR 565 begins at an intersection with US 206 and the northern terminus of Route 15 in Frankford Township, heading northeast on two-lane undivided Ross Corner-Sussex Road.

The road runs through hilly areas of woods and farms with a few homes, continuing into Wantage Township.

CR 565 turns east to form a concurrency with Route 23 on a three-lane road with a center left-turn lane, passing a few businesses.

Upon splitting from Route 23, CR 565 heads east on two-lane undivided Glenwood Road.

This stretch of roadway passes through areas of woods and residential neighborhoods and crosses the Appalachian Trail.