Cranberry Run is a tributary of Catawissa Creek in Columbia County, Pennsylvania, in the United States.

Cranberry Run begins on Catawissa Mountain in Beaver Township.

After crossing Cranberry Run Road, it turns northeast and reaches its confluence with Catawissa Creek after a few hundred feet.

[1] Cranberry Run joins Catawissa Creek 18.57 miles (29.89 km) upstream of its mouth.

[3] A total of 2.0 miles (3.2 km) of Cranberry Run is considered to be impaired by atmospheric deposition due to pH.

[5] The elevation near the mouth of Cranberry Run is 754 feet (230 m) above sea level.

[1] The lower reaches of Cranberry Run are on rock of the Mauch Chunk Formation.

[5] Cranberry Run is in the United States Geological Survey quadrangle of Shumans.

[7] Cranberry Run is considered by the Pennsylvania Department of Environmental Protection to be a coldwater fishery.