The stream is considered to be a High-Quality Coldwater Fishery and Class A Wild Trout Waters.

Klingermans Run begins on Catawissa Mountain in Roaring Creek Township.

A few tenths of a mile downstream, it reaches its confluence with Catawissa Creek near Beaver Station Road.

[2] Klingermans Run joins Catawissa Creek 17.08 miles (27.49 km) upstream of its mouth.

[2] The lower reaches of Klingermans Run are on rock of the Mauch Chunk Formation.

The headwaters of the stream are in Pennsylvania State Game Lands Number 58, as is the rest of the upper half of the watershed.

[6] Klingermans Run is in the United States Geological Survey quadrangle for Shumans.

[4][6] The stream is considered by the Pennsylvania Fish and Boat Commission to be Class A Wild Trout Waters between its headwaters and its mouth.