Custom peptide synthesis

[2] Large scale custom peptide synthesis can be carried out either in a liquid solution or in solid phase.

Solid phase peptide synthesis (SPPS) can be carried out either manually or in a fully automated fashion.

Manual synthesis for short peptides is advantageous as it allows for more flexibility when scaling up and it permits troubleshooting of unexpected problems with more ease.

The synthesised peptides must undergo a QC procedure by analytical HPLC and mass spectrometry.

For this, gram to multi-gram scale may be needed in order to initiate small animal studies.