[2] The refuge was established in 1990 under the authority of the Emergency Wetlands Resources Act of 1986.

Cypress Creek is a popular area for both waterfowl and upland game hunters.

Hunting of geese, ducks, whitetail deer, rabbits, squirrels, quail and doves is permitted on most parts of the refuge.

Although administered by the United States Fish and Wildlife Service, the Refuge is part of the Cache River Wetlands Joint Venture Partnership, a confederation of state and federal agencies, non-profit groups, and private landowners with the common goal of preservation and restoration of the Cache River.

This article incorporates public domain material from websites or documents of the United States Fish and Wildlife Service.