These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain.

They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts.

Dynamins can also self-assemble, a process that stimulates GTPase activity.

Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.

[7] DNM2 has been shown to interact with: Mutations in this gene have been associated to cases of acute lymphoblastic leukaemia,[10] or congenital myopathy (centronuclear type).