He started all 14 games in his senior season and was a team captain, totaling 72 catches for 1,111 yards receiving and seven touchdowns.

[16] Goedert was the third tight end drafted in 2018 and was selected as a replacement for Brent Celek, whom the Eagles released on March 13, 2018.

[22] In the Wild Card Round of the playoffs against the Chicago Bears, Goedert caught a 10-yard pass in the end zone from Eagles quarterback Nick Foles.

Goedert also made a good play in catching a low pass, breaking a tackle, and running for a first down on another 10-yard reception, during the Eagles' winning touchdown drive.

[25] In a must-win Week 17 matchup against the New York Giants, Goedert contributed to a 34–17 road victory after recording four receptions for 65 yards, clinching the NFC East title for the second time within three seasons.

[29] Goedert was assaulted in a South Dakota bar on June 22, 2020, and briefly received treatment at a hospital.

[41] Goedert was placed on injured reserve on November 16, 2022, after suffering a shoulder injury as a result of a facemask penalty that went uncalled.

[45] Goedert reached Super Bowl LVII where he had six catches for 60 yards, but the Eagles lost 38–35 to the Kansas City Chiefs.

[51] On December 7, Goedert was placed on injured reserve due to a knee injury sustained during Week 13's matchup against the Baltimore Ravens, with plans for him to return for the playoffs.

[53] On January 12, 2025, Goedert recorded a touchdown during the Wild Card Round playoff game against the Green Bay Packers.

[54] Goedert won Super Bowl LIX on February 9, 2025, recording two receptions for 27 yards in a 40–22 victory against the Kansas City Chiefs.