He previously served as the offensive coordinator for the Indianapolis Colts from 2018 to 2020 and as an assistant coach with the San Diego/Los Angeles Chargers from 2013 to 2017 and the Kansas City Chiefs from 2009 to 2012.

[3] Sirianni played wide receiver at Division III Mount Union in Alliance, Ohio, winning national championships in 2000, 2001, and 2002.

[16][17] Two months later, the Eagles traded quarterback Carson Wentz to the Colts, leaving former second-round pick Jalen Hurts as the presumed starter.

[19] On September 12, 2021, Sirianni made his regular-season head coaching debut against the Atlanta Falcons and led the Eagles to a 32–6 victory.

[21] The Eagles lost in the Wild Card Round of the playoffs to the defending Super Bowl champion Tampa Bay Buccaneers 31–15.

[24] The 2022 Eagles compiled a 14–3 record in the regular season, earning the NFC East division championship and a first-round bye in the playoffs.

[27] One notable sideline incident occurred during a Week 11 away matchup against the Indianapolis Colts, where Sirianni had previously served as an offensive coordinator.

[42] After a week 6 home victory over the Cleveland Browns, Sirianni drew criticism for having a shouting match against the Eagles' fans in attendance behind the team's sideline.

[43][44] While the Eagles were on the field in victory formation, TV cameras showed that Sirianni walked behind the bench, put an index finger to his right ear then shouted words that could not be heard from afar[45] but were interpreted as, "I can't hear you.

[43] Despite early struggles and a 2-2 start, Sirianni coached the Eagles to a 14–3 regular season record and an NFC East title.

[47][48] Propelled by the 2024 addition of runningback Saquon Barkley and an astounding defensive turnaround from the prior season under the leadership of Defensive Coordinator Vic Fangio, the Eagles secured a Wild Card Round victory over the Green Bay Packers and a Divisional Round victory over the Los Angeles Rams.