It is located on College Hill in the center of the campus,[3] on the northern side of a quadrangle also consisting of Rush H. Kress Hall to the west, Harland A. Trax Hall to the east, and the Carnegie Building to the south.

Beyond its northern side, at the foot of the Grove, University Avenue was the former main approach road to the campus.

[5] Designed by Thomas U. Walter,[3] Old Main was built in 1858, when the institution was named the University at Lewisburg.

[6] After Old Main was damaged by fire in 1932, it was rebuilt between 1935 and 1937 and renamed for university trustee Daniel C.

[4][8] Today, the building offers housing for the university's sophomore students.