The following seasons were marked by continuous injuries, resulting in Neres playing a limited number of games and declining in performances, leading him to move to Shakhtar Donetsk.

After representing Brazil at various youth levels, Neres was called up to the full international team for the first time in March 2019, and was part of the squad that won the 2019 Copa América.

In his third season, Neres scored his first official European goal against Standard Liège in the second leg of the third qualifying round of the Champions League.

In January, Guangzhou Evergrande made a £36.9 million bid on Neres,[9] but Ajax ultimately refused, because they wanted to keep the team together to win prizes that year and make it far in the UEFA Champions League.

In the second leg in the round of 16 of the UEFA Champions League, in a memorable game against Real Madrid, Neres scored the second goal to give Ajax the lead on aggregate, and the Dutch side eventually won the tie by a margin of 5–3, thus knocking the three-time defending European champions out of the competition.

[12] Despite reported interest from the likes of Manchester United and Atlético Madrid, Neres signed a new contract with Ajax on 7 August 2019 that runs through 2023.

Since Ajax acquired Mohamed Daramy and Steven Berghuis as wingers at the beginning of the season, competition for Neres increased, as a result of which he was often no longer included in the starting lineup.

[18] On 20 June 2022, Neres signed a five-year contract with Primeira Liga side Benfica, for a reported fee of €15.3 million.

[20] He made his debut for the club on 2 August, providing two assists to Gonçalo Ramos in the 4–1 home win over Midtjylland in the 1st leg of the 2022–23 UEFA Champions League third qualifying round.

[21] On 23 August, Neres scored his first goal for the club and provided an assist in the 3–0 home win over Dynamo Kyiv in the 2nd leg of the 2022–23 UEFA Champions League play-off round, helping his side qualify to the tournament.