He is best known for the motion analysis of living cells, the discovery of Candida albicans phenotypic switching and monoclonal antibody technology.

Soll directed the Developmental Studies Hybridoma Bank from 1995 to 2021, and the WM Keck Dynamic Image Analysis Facility from 1985 to 2021.

[1] A recipient of more than seventy-eight grants and contracts,[2] he has also founded four companies, and is active on several editorial boards for major scientific publications.

[3][4] Soll was born in South Philadelphia, Pennsylvania, and graduated from Central High School for Boys in 1959 with a bachelor of arts degree.

In 1989, he was awarded the Roy J. and Lucille Carver/Emil Witschi Professorship of the Biological Sciences; he also became a full professor of Dentistry that same year.

From 1965 to 1970, Soll worked on the germination of Blastoclandiella emersonii under the mentorship of David Sonneborn and discovered that complex differentiations can be preprogrammed and occur without RNA or protein synthesis.

[8] Between 1985 and 1987, Soll and his colleagues discovered the first high frequency switching system in the pathogenic yeast Candida albicans.