De La Salle College, Colombo is the only school in Sri Lanka dedicated to the Patron Saint of Christian Teachers St. John Baptist de la Salle, founder of the congregation of De La Salle Brothers of the Christian Schools in Latin: "Fratres Scholarum Christianarum"(FSC).

The college was inaugurated on 1 February 1905 by the LaSallian Brothers.

Rev Br Luke Gregory, introduced a house system, with four houses: Edward, Augustine, Luke and Hermenegild, each named after a De La Salle brother.

The Mazenodian-LaSallian (The Battle of the DEs) was an annual cricket encounter between De Mazenod College, Kandana and De La Salle College, Mutwal in since 1955.

It is known as The Battle of the DEs due to the names of the two schools.