The assumed course of study is the Smart Core curriculum developed by the Arkansas Department of Education.

Students may engage in regular and Advanced Placement (AP) coursework and exams prior to graduation.

De Queen has been accredited by AdvancED (formerly North Central Association) since 1933.

For 2012-14, the De Queen Leopards participate in the 5A South Conference for interscholastic activities administered by the Arkansas Activities Association (AAA) including baseball, basketball (boys/girls), cheer, cross country, SOCCER (boys/girls), football, archery, golf (boys/girls), softball, tennis (boys/girls) and track and field (boys/girls).

[4] The Leopards boys track and field teams have won 13 state championships between 1958 and 2009 with the boys cross country team taking home four state titles between 2002 and 2011.