Greenbrier High School is the home of the pilot program that formed the national EAST Initiative.

The assumed course of study follows the Smart Core curriculum developed the Arkansas Department of Education (ADE), which requires students to complete 22 credit units before graduation.

In 2011, Greenbrier School District and its high school were recognized in the AP District of the Year Awards program in the College Board's 2nd Annual Honor Roll that consisted of 367 U.S. public school districts (4 in Arkansas) that simultaneously achieved increases in access to AP® courses for a broader number of students and improved the rate at which their AP students earned scores of 3 or higher on an AP Exam.

The school athletic activities include baseball, basketball (boys/girls), soccer (boys/girls), bowling, competitive cheer, cross country (boys/girls), football, golf (boys/girls), softball, swimming and diving (girls), tennis (boys/girls), volleyball, and wrestling (boy/girls).

[8] On March 14, 2018, during the 2018 United States gun violence protests, three students elected to receive corporal punishment in the form of two paddlings on the thighs for their participation in the walkout.