Nettleton High School is a comprehensive four-year public high school located in Jonesboro, Arkansas, United States.

The assumed course of study at Nettleton High School is the Smart Core curriculum developed by the Arkansas Department of Education.

Students are engaged in regular and Advanced Placement (AP) coursework and exams prior to graduation, with the opportunity for qualified students to be named honor graduates based on grade point average and additional coursework above minimum requirements.

For 2012–2014, the Nettleton Raiders participate in the 5A East Conference administered by the Arkansas Activities Association (AAA).

The Nettleton Quiz Bowl team placed 2nd at the 2017 AGQBA State Tournament[7]