[6] The assumed course of study follows the Common Core curriculum developed by the ADE.

The Wynne Yellowjackets participate in numerous interscholastic sports and events in the 5A-East Conference administered by the Arkansas Activities Association including: baseball, basketball (boys/girls), cheer, cross country (boys/girls), dance, football, golf (boys/girls), soccer (boys), softball, tennis (boys/girls), track (boys/girls), and volleyball.

34 jersey of NFL running back and Wynne alumnus DeAngelo Williams who ran for 2,204 yards and 34 touchdowns in 2001.

[7] The Yellowjackets softball team are two-time state champions, picking up titles in 2009 and 2011.

On March 31, 2023, a tornado struck and heavily damaged the school and surrounding town.