2A1R, 2A1S, 3CTR507374108ENSG00000140694ENSG00000274829ENSMUSG00000022685O95453Q8VDG3NM_001134477NM_001242992NM_002582NM_028761NM_001358452NM_001358453NP_001127949NP_001229921NP_002573NP_083037NP_001345381NP_001345382Poly(A)-specific ribonuclease (PARN), also known as polyadenylate-specific ribonuclease or deadenylating nuclease (DAN), is an enzyme that in humans is encoded by the PARN gene.

[5][6] Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs.

The amino acid sequence of poly(A)-specific ribonuclease shows homology to the RNase D family of 3'-exonucleases.

[6] Hereditary mutations in PARN lead to the bone marrow failure disease dyskeratosis congenita which is caused by defective telomerase RNA processing and degradation in patients.

This article on a gene on human chromosome 16 is a stub.