Her father was a Navy aviator who completed two tours of duty in the Vietnam War,[4] and her mother worked as a real estate agent.

[6] Myers met her husband, Todd Purdum, the national editor for Vanity Fair, former White House correspondent, and Los Angeles bureau chief for The New York Times, during the 1992 presidential campaign.

[6][7] Myers' career in political communications began shortly after graduating from college, taking a full-time role on the 1984 presidential campaign of Walter Mondale.

[21] In 1997, she was the winning contestant on an episode of Celebrity Jeopardy!, beating Robert F. Kennedy, Jr. and Representative Jesse Jackson, Jr.[22] Myers has also appeared as a guest on other television programs, including The Today Show,[23] Charlie Rose,[24] and ABC's Nightline.

Writer Aaron Sorkin recruited Myers to serve as a consultant and script advisor on the Emmy Award-winning TV series The West Wing, beginning in 1999.

The character of C. J. Cregg (played by Allison Janney), the White House Press Secretary on the series, was partially inspired by Myers.

[26][27] News articles have also reported that she may have served as the basis for the character of Daisy Green in the novel and film Primary Colors, played by Maura Tierney.

[6] Since leaving the White House, Myers has also been invited to speak at numerous events, usually on the topics of women's issues, the media and politics.