Demegestone, sold under the brand name Lutionex, is a progestin medication which was previously used to treat luteal insufficiency but is now no longer marketed.

[7] It has also been studied in combination with estrogens, such as moxestrol, as an oral contraceptive and treatment for infertility.

[6][8][2] It is a highly potent progestogen, showing 50 times the potency of progesterone in the Clauberg test.

[13] In a particular bioassay, both demegestone and progesterone showed antiglucocorticoid rather than glucocorticoid activity.

[2] Demegestone, also known as 17α-methyl-δ9-19-norprogesterone or as 17α-methyl-19-norpregna-4,9-diene-3,20-dione, is a synthetic norpregnane steroid and a derivative of progesterone.

[4] Demegestone is the generic name of the drug and its INNTooltip International Nonproprietary Name.