[2] In 2006, IDW announced that Calero would be one of the cover artists on its six-issue Star Trek: The Next Generation TV tie-in miniseries The Space Between, scheduled for 2007.

That same year, he drew the Dark Horse Comics relaunch of the former Gold Key and Valiant character, Doctor Solar, Man of the Atom, which was written by Jim Shooter.

In a positive review, Booklist expressed that Calero "shows off a virtuoso command of the format and impressive knowledge of his horror antecedents with the visuals.

He has provided interior artwork for Dungeons & Dragons books for the Forgotten Realms including Silver Marches, Faiths and Pantheons, and Races of Faerûn.

[citation needed] Devil Inside, based upon a webcomic co-created by Dennis Calero and actor Todd Stashwick, was optioned in 2011 for development.