Lakka Souliou (Greek: Λάκκα Σουλίου) is a former municipality in the Ioannina regional unit, Epirus, Greece.

Lakka Souliou has been inhabited since the Neolithic period, as it is testified by the fossils which were found in the region, like axes made of granite and flint, coppery and iron weapons, vessels of clay as well.

There are traces of Pelasgic walls in many places of the region, like in Achladea, Bestia, Sistrouni, Alepochori and Paleochori Botsari.

Homer mentions[citation needed] that the first historical people who inhabited the region were the Pelasgians in the early 3rd millennium BC, while several Greek tribes started to migrate there from Thessaly in the early 2nd millennium BC, among which the Selloi, Chaonians, Thesprotians and Molossians were included.

The Thesprotians dominated upon the other tribes and they expanded eastward from their initial settlement, to the Epirus coastline and present-day Lakka Souliou was included in their possession.

It is then that the inhabitants of the Souli area, the famous Souliotes began the ceaseless struggle against the Ottoman Turks and later, around 1600, they formed the Souliote Confederation, an autonomous confederacy dominating a large number of neighbouring villages in the remote mountainous areas of Epirus, where they could successfully resist Ottoman rule.

In 1940, the Lakkiotes were also involved in the war against the Axis powers, the defeat of the invasion of Benito Mussolini's forces to Greece and the pushing of them back to Albania, in World War II, and they fought along with Napoleon Zervas against Nazi Germany, while Lakka Souli suffered a lot during the Axis occupation of Greece.