The village has a permanent population of 468 (2021 census),[1] however, in the summer months the numbers can soar past 1000 as expatriates return from abroad (e.g. Sweden, Germany, USA, Canada) and from Athens and other larger cities.

More local theories suggest the name was derived from old myths of ancient river dwellers known as "Mouses" (Greek: Mούσες) or from a queen who resided in what is now the ruins of a castle dating back to the 3rd century AD.

[3] As late as 1880, Mousiotitsa is described by Greek sources of that era (Labridis) as one of the exclusively Albanian-speaking villages of Tsarkovista (today Dodoni).

It was part of an Albanian-speaking enclave of villages (including Zermi, Krania, Papadates, Rousatsa, Derviziana, Mousiotitsa) in the upper Acheron region.

This was in reprisal for a deadly attack on a German officer in the nearby area of Zita, and resulted in 17 more locals being murdered, raising the total number of victims to 153.