The museum was opened on July 1, 2019 by Mrs. Hedy d'Ancona with an exhibition dedicated to the work of two designers, Milton Glaser and Wim Crouwel, both of whom were 90 years old at the time.

[citation needed] The interior consists of seven ceiling paintings by Jacob de Wit, at least five upper door pieces and fourteen grisailles by the same artist.

There are also tapestries by the firm Leyniers [nl] from Brussels, panelling, gold leather wall covering, a mirror with decoration by Jacob de Wit representing an allegory of inheritance, fireplaces, crystal chandeliers, most with representations of Ovid's Metamorphoses.

[7][8][9] After the Anschluss in 1938 by the Nazi's, the interior was destined for the Führermuseum in Linz (not realized) and stored in salt mines in Altaussee (Austria).

A ceiling painting by Jacob de Wit, twice enlarged, from the Dedel House is located in Waddesdon Manor and chandeliers are hanging in the Neue Burg in Vienna.

The wallpaper library can be accessed primarily at the International Institute of Social History in Amsterdam and partly in Dedel House.