Dessau Hauptbahnhof is the main passenger station in the city of Dessau-Roßlau in the German state of Saxony-Anhalt.

Located on its south-eastern frontage is a stop for trams and buses operated by the Dessauer Verkehrsgesellschaft, the city's public transport company.

Dessau had an important role in rail transport from the early days of railways in Germany because of the crossing over the Elbe to its north.

Because of the location of several industrial enterprises in the region, such as the Junkers aircraft factory, the railway was very important for rail freight.

While the station was formerly a stop for InterRegio and Intercity trains, it is now almost exclusively served by regional transport as Dessau is not located on the busy Berlin–Halle and Magdeburg–Halle–Leipzig lines.