is a 2005 action-adventure video game developed by Pandemic Studios and published by THQ for PlayStation 2, Xbox, and mobile phones.

franchise, and is set in 1959 in the United States, and parodies the lifestyles, pop culture, and political attitudes of this time period.

All buildings and structures in these environments can be destroyed (save for trees and rocks), and humans can become alarmed by Crypto's presence at these locations.

Neutral NPCs frequently refer to pop culture of the 1950s, such as the Edsel, Marilyn Monroe, and 'Ike' Dwight D. Eisenhower when scanned by Crypto.

In keeping with the Cold War setting, hostile NPCs refer to Crypto as a 'commie' with his various actions covered up in news stories as communist attacks.

Military technology in the game is depicted as being far more advanced than it actually was in the 1950s, with the US Army having possession of sentry guns, automated anti-air batteries, gigantic, ultra-radioactive tesla coils, and mechanized walkers.

Furons are named after diseases (such as Orthopox and Cryptosporidium) and are a highly advanced race who use their technology for harsh, unsympathetic science and vicious war.

Unregulated atomic weaponry caused a fatal mutation in the Furon race whereby they could no longer reproduce due to their lack of genitalia.

Crypto arrives at Turnipseed Farm in the Southern United States, where Pox mistakes cows for Earth's dominant life form.

After several missions in the Midwestern town of Rockwell and the California suburb of Santa Modesta, Crypto and Pox become aware of the Majestic and begin crippling government attempts to stop them by performing acts such as destroying Area 42 with an atomic bomb and defeating his recurring foe, Armquist, the head of the army.

After being temporarily captured in Union Town, the game climaxes in Capitol City, where Crypto assassinates President Huffman and slaughters all members of Congress.

The game ends with Huffman making a televised speech, assuring America that the recent events were the work of communists, who have poisoned the U.S. water supply, and that, as a result, testing centers have been set up all across the country to scan people for harmful toxins.

In Destroy All Humans!, players assume the role of Cryptosporidium 137 (Crypto for short), a warrior and member of the Furons, a race of war-like extraterrestrials with a large empire constantly seizing new worlds through conquest.

The saucer is equipped with a Death Ray which can burn humans, vehicles, and buildings; the "Abducto Beam", a tractor ray that can lift up people and objects and hurl them into the air, and can capture people making them alien abduction; the Quantum Deconstructor; a highly powerful nuclear weapon that can launch radioactive bombs that utterly destroy anything in this radius that detonates at; and the "Sonic Boom", a bomb that can explode on contact and shock the blast radius like a tremor.

On foot, Crypto has an arsenal of four weapons, of which include the Zap-O-Matic, a gun that emits an electric charge, shocking its victims; the Anal Probe, a powerful rod that goes into the victim's rectum and uproots a DNA-enriched brain: the Disintegrator Ray, which turns the target's flesh and organs into ashes and renders only a charred skeleton; and the Ion Detonator, the Furon equivalent of a grenade launcher.

The HoloBob requires PSI energy, called "concentration" in the game, which can be continually replenished by reading the thoughts of unknowing humans or other animals.

Being a science fiction fan, Harding even thought of using the concept of playing as an alien invader, something that he had not seen in a video game and served as a "premise for getting to do mindless destruction that makes sense".

[27] Maxim gave it a score of eight out of ten and said: "Set up like Grand Theft Alien, there are tons of missions to complete, though you can also just roam around, killing filthy humans and destroying their stuff".

[28] The New York Times also gave it a favorable review, but commented that "it's a shame the gameplay lacks the almost flawless perfection of Destroy All Humans' story and presentation".

Big Willy Unleashed, a spin-off set in the 1970s in which Pox and Crypto run a fast-food chain, and Destroy All Humans!

[31] Jim Dauterive, previously of King of the Hill, was to be a writer and executive producer of the TV version of Destroy All Humans!.

In 2019, THQ Nordic announced a remake of Destroy All Humans!, set for a release in 2020 for Microsoft Windows, PlayStation 4, and Xbox One.