The player controls Cryptosporidium 137 ("Crypto" for short), an alien who arrives on Earth in 1950s America to harvest human DNA.

[8] Crypto is equipped with a vast arsenal of alien weapons such as the Zap-O-Matic and Anal Probe, to defeat enemies.

[10] Players can perform movements such as gliding and dashing, and they can chain actions together such as shooting enemies while levitating them.

Crypto is protected by a shield, which informs players the direction of hostile attacks.

[12] The original game's dialogue and humor remained intact, though the team enhanced them by updating the character models and cutscenes and introducing motion capture.

[13] Instead of re-recording the lines, the team used the audio from the original game and improved its quality for the remake.

In 2017, the firm reaffirmed that the company realized the demand for a new game in the series and added that they were exploring options to revitalize the franchise.