It also marks the final game in the series to be developed by Pandemic Studios, as the company was later acquired by Electronic Arts in 2007.

His clone, Cryptosporidium-138 (Crypto for short), made of more pure Furon DNA, is now taking his place and continuing to pose as the President of the United States.

After saving Bay City from annihilation at the hands of the Soviets, Crypto discovers that the KGB have fled to Albion and promptly follows, where he meets Reginald Ponsonby-Smythe, the James Bond-esque head of M16 (a parody of MI6), and a rogue KGB agent named Natalya Ivanova, to whom Crypto is attracted.

After killing Ponsonby and puzzling over his cryptic reference that the Furons may not be the only aliens on Earth, Crypto learns that the KGB have a base on Takoshima Island.

Arriving in Takoshima, Crypto has to rescue a person that calls himself Dr. Go (a parody of Julius No) from the Black Ninjas and KGB.

Inside Crypto and Natalya are addressed by the mastermind behind the spore plot, Soviet Premier Milenkov (a parody of Ernst Stavro Blofeld).

Milenkov shows a film clip of his men using spores on a Takoshimese intern, who transforms into a giant Godzilla-like monster called "Kojira".

Using his ability to "body snatch", Crypto disguises himself as Soviet cosmonaut Leonid, the head scientist on the Moon, and convinces the rest of the humans to go to war with the Blisk.

Crypto and Natalya battle for their various species to save the Earth by attacking and successfully destroying the Blisk Hive Mind with the O.M.G.W.T.F.

[1] The player is now able to call their saucer from an empty landing site in order to eliminate backtracking, and the UFO can now cloak for limited periods of time.

[3] There are 5 new weapons: the Dislocator, which shoots levitating purple disks that take targets with them; the Meteor Strike, which fires up to 3 meteors at the crosshairs; Gastro--the mother ship's former janitor who, like Pox, uploaded himself into a hologram--who shoots at nearby enemies before self-destructing; the Burrow Beast, which shoots out a lure for a giant space worm to crawl around, eating nearby humans; and the Anti-Gravity Field, which creates a small point of high gravity, pulling anything nearby--including humans--into it before exploding.

[21] The Times gave it four stars out of five: "The tone is jocular, the script humorous and well acted by, among others, Little Britain’s Anthony Head".

[20] The Sydney Morning Herald gave it three-and-a-half stars out of five and called it "a minor improvement over the original, with just as many silly sci-fi shenanigans".