Deuterated DMSO, also known as dimethyl sulfoxide-d6, is an isotopologue of dimethyl sulfoxide (DMSO, (CH3)2S=O)) with chemical formula ((CD3)2S=O) in which the hydrogen atoms ("H") are replaced with their isotope deuterium ("D").

Deuterated DMSO is a common solvent used in NMR spectroscopy.

Deuterated DMSO is produced by heating DMSO in heavy water (D2O) with a basic catalyst such as calcium oxide.

The reaction does not give complete conversion to the d6 product, and the water produced must be removed and replaced with D2O several times to drive the equilibrium to the fully deuterated product.

[2] However commercially available samples are not 100% pure and a residual DMSO-d5 1H NMR signal is observed at 2.50ppm (quintet, JHD=1.9Hz).