She studied economics at the National University of Córdoba where she received the gold medal for her academic performance and best grade point average.

[2][5] She founded Rysk Analysis in 1991, and subsequently worked in various private companies, including Loma Negra, S&P Global Ratings, and Banco Supervielle.

[6] Mondino works at UCEMA as a Finance professor in the Bachelor's Degree in Business Administration and Marketing, among several courses, including for international students.

[8] On October 31, 2023, in an interview with journalist Luis Novaresio for his program on La Nación +, Mondino generated controversy with her statements in defense of the idea of an "organ market"[9] and by comparing equal marriage with having lice, maintaining that "As a liberal I agree with each person's life project.

[11] Mondino has assets according to her sworn statement of 5,027 million pesos, which makes her the richest official among the ministers appointed by Javier Milei to be part of his cabinet.