Karina Elizabeth Milei (Spanish pronunciation: [kaˈɾi.na e.li.saˈβ̞eð̞ miˈlei̯]; born 28 March 1972) is an Argentine politician, current General Secretary of the Presidency of the Argentine Nation since her designation by her brother the President of Argentina, Javier Milei on 10 December 2023.

Javier Milei often refers to her as "The Boss" ("El Jefe" in Spanish, using the male form of the noun instead of the feminine "La Jefa"), always highlighting her as one of his main advisors.

Javier remained distant from his parents, with Karina being his only family member with whom he maintained contact for many years.

He stated that their father subjected him to severe beatings and tried to seek protection from his sister.

Karina also studied to be a pastry chef, sculptor and tarot reader, activities that she did as hobbies and work.