Diego Hurtado de Mendoza, 3rd Duke of the Infantado

Diego Hurtado de Mendoza y Luna, 3rd Duke of the Infantado, nicknamed El Grande, (Arenas de San Pedro, Spain, 11 March 1461 – Guadalajara, Castile-La Mancha, Spain, 30 August 1531) was a Spanish noble.

He was the son of Íñigo López de Mendoza y Luna, 2nd Duke of the Infantado (* Guadalajara, Castile-La Mancha, 1438 - Guadalajara, Castile-La Mancha, 1500) and the grandson of Diego Hurtado de Mendoza, 1st Duke of the Infantado, (* Guadalajara, Castile-La Mancha, 1415 - Manzanares el Real, 1479).

He was a strong political opponent of Cardinal Cisneros and defended the rights of the nobles.

In 1519, he became a Knight of the Order of the Golden Fleece on proposal of King Charles I of Spain, a.k.a.

During the Revolt of the Comuneros in 1520 and 1521, the duke of Infantado played a cautious waiting game to see which side would win.