[1] In places where infections are not common, it is a second line treatment after paromomycin when a person has no symptoms.

[citation needed] For people who are symptomatic, it is used after treatment with ambecides that can penetrate tissue, like metronidazole or tinidazole.

Diloxanide furoate is not recommended in women who are breast feeding, and in children <2 years of age.

[5] Diloxanide furoate destroys trophozoites of E. histolytica and prevents amoebic cyst formation.

[4] The drug was discovered by Boots UK in 1956, and introduced as Furamide; it was not available in much of the developed world as of 2012.