Dimethylglycine (DMG) is a derivative of the amino acid glycine with the structural formula (CH3)2NCH2COOH.

Dimethylglycine has been suggested for use as an athletic performance enhancer, immunostimulant, and a treatment for autism, epilepsy, or mitochondrial disease.

[2] Published studies on the subject have shown little to no difference between DMG treatment and placebo in autism spectrum disorders.

[5] This compound is commercially available as the free form amino acid, and as the hydrochloride salt [2491-06-7 ].

In this reaction, glycine is treated with aqueous formaldehyde in formic acid that serves as both solvent and reductant.