In 1906, he became the first student of Konstantinos Parthenis, a distinguished Greek painter, while he was studying at the National Technical University of Athens civil engineering, graduating in 1908.
Among them is the formation of the archaeological site around the Acropolis and Philopappou hill, perhaps his most important work, and the tourist pavilion of St. Demetrios Loubardiaris, seeking its ideal.
He has been often described as a founding father of critical regionalism by notable architectural historians and theorists, including Alexander Tzonis & Liane Lefaivre and Kenneth Frampton.
[3] In 1933, Pikionis with other Greek architects signed the Athens Charter, a manifesto of the modernist movement which published later by Le Corbusier.
Utilizing rough-finished marble in various shapes that appear irregular, yet are strictly geometric, and incorporating expertly chosen local fora on his terraces and steps, Pikionis' work has astounded visitors to the area and remains highly thought of ever since.
He utilized similar techniques in creating the children's playground of the municipality of Filothei, an affluent Athens suburban area.