In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation.

[6] This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction.

This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain.

[5] Alternative splicing in the 5' UTR of the DDR2 gene results in multiple transcript variants encoding the same protein.

[10] This article incorporates text from the United States National Library of Medicine, which is in the public domain.