Disulfiram-alcohol reaction (DAR) is the effect of the interaction in the human body of alcohol drunk with disulfiram or some types of mushrooms.

[1][2] The DAR is key to disulfiram therapy that is widely used for alcohol-aversive treatment and management of other addictions (e.g. cocaine[3][4] use).

[5][6] Once disulfiram-treated patients take alcohol, even in small doses, they experience strong unpleasant sensations (flush, nausea, lightheadedness, headache, sweating, vomiting, and vertigo).

[11][12] Disulfiram inhibits several human aldehyde dehydrogenases (ALDH),[13] most importantly the version coded for by gene ALDH2 which metabolizes acetaldehyde.

[23] They include lurid bolete (Boletus luridus),[24] inky cap (Coprinopsis atramentaria),[25][26] and club-foot (Clitocybe clavipes).