[1][2][3] The film uses the concept of three female singers who, "as they sing their way through life's ups and downs, they build a friendship strong enough to last a lifetime.

"[4] In an attempt to salvage their group's music career, Reggie Mendoza (Regine Velasquez), a self-confessed lola's girl, and Mikki Tolentino (Mikee Cojuangco), a man-hating tomboy and breadwinner of her family, discover Donnette Legaspi (Donna Cruz), a vainglorious, and spoiled rich girl, to be part of their musical trio, DoReMi.

Due to this mishap, the girls travel to an unknown rural province, putting themselves in a self-imposed exile after the embarrassment they faced after chasing their dreams.

While still considering the idea of becoming successful in the music industry, the girls help convert a small local restaurant into a mini bar where they can perform to sustain their daily needs and expenses.

As Reggie pursued a career as a successful solo singer, Donnette channeled her efforts to help orphans and other abused children in social welfare, and Mikki, started her own family, and food business with Toto (Gary Estrada), whom she met and fell in love with in the province.