22845227697ENSG00000175283ENSMUSG00000075419Q9UPQ8Q8R2Y3NM_014908NM_177648NP_055723NP_808316In enzymology, a dolichol kinase (EC 2.7.1.108) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are CTP and dolichol, whereas its two products are CDP and dolichyl phosphate.
The systematic name of this enzyme class is CTP:dolichol O-phosphotransferase.
[5][6][7] Dolichyl monophosphate is an essential glycosyl carrier lipid for C- and O-mannosylation and N-glycosylation of proteins and for biosynthesis of glycosylphosphatidylinositol anchors in endoplasmic reticulum (ER).
[8] Mutations in DOLK cause a subtype of the congenital disorders of glycosylation, DOLK-CDG (CDG-Im).
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