In enzymology, a dolichyl-phosphate-mannose-protein mannosyltransferase (EC 2.4.1.109) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are dolichyl phosphate D-mannose and protein, whereas its two products are dolichyl phosphate and O-D-mannosylprotein.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases.
The systematic name of this enzyme class is dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase.
Other names in common use include dolichol phosphomannose-protein mannosyltransferase, and protein O-D-mannosyltransferase.
A human gene that codes for this enzyme is POMT1.