The Dome Rock Mountains are on the southwest of the regional Maria fold and thrust belt.

The Dome Rock Mountains are a north-south trending range about 30 miles (48 km) long.

The Palo Verde Valley borders the range on the west, adjacent to the Colorado River.

Interstate 10 bisects the range connecting Ehrenberg on the Colorado River with Quartzsite to the east of the mountains.

The western mountain washes drain to the Colorado River, and the eastern washes drain into the La Posa Plain and the north-flowing Tyson Wash.[1] The northern portion of the mountains can be accessed from the west via Arizona State Route 95; from the east through the Colorado River Indian Reservation, and I 10.