From south to north, it passes through the neighbourhoods of Todmorden Village, Flemingdon Park, Don Mills, Graydon Hall, Henry Farm, Parkway Forest, and Don Valley Village.

[1] This section is called The Peanut due to its shape on a topographic map.

[2] Originally named Don Independent Road due to donations of the land by local farmers for the public improvement, the road was carrying traffic from many mills in the area: flour, grist, woollen, and sawmills, hence the current name.

Since November 2002, Don Mills station located under Fairview Mall has served as a connection between the Sheppard subway line and a multitude of other bus routes.

There are plans by the Toronto Transit Commission to run streetcars on Don Mills from Steeles to Overlea Boulevard to Pape station with the Don Mills LRT, as part of the Transit City plan.