The 11,700 acres (4,700 ha) Dos Cabezas Mountains Wilderness lies 20 miles (32 km) east of Willcox and 7 miles (11 km) south of Bowie in Cochise County.

The wilderness consists of the rugged slopes of the Dos Cabezas Mountains, with elevations ranging from 4,080 to 7,500 feet (1,200 to 2,300 m).

There is a diverse terrain of steep mountain slopes, granite outcroppings and vegetated canyon floors.

Several developed and natural springs in the wilderness provide water for the abundant wildlife.

As of 2021[update], the Arizona Game and Fish Department has been releasing photos of a jaguar that has been seen in this area since November 2016 with 45 documented events.