Anthony Joseph Drexel was raised a Roman Catholic, but he joined the Episcopal Church later.

Over the next generation, this partnership assumed the leading role in financing America's railroads and stabilizing and revitalizing Wall Street's chaotic securities markets.

Drexel married Ellen B. Rozet (1832–1891), the daughter of John Roset (1794–1870) and Mary Ann Laning (1807–1880) in 1850 in a service officiated by Dutch Reformed clergyman Rev.

He and his family were members of the Church of the Saviour, now Philadelphia Cathedral, where Drexel served first as a vestryman, and later as warden.

[14] Drexel died of a heart attack on June 30, 1893, in Karlsbad (in the German-speaking part of Bohemia, Austrian Empire), today Karlovy Vary, Czech Republic, at the age of 66, and was buried in Woodlands Cemetery in Philadelphia.