He made his MLB debut in 2021 and started the fourth game of the 2021 World Series for the Atlanta Braves.

[6] Lee split his professional debut season of 2016 between the Gulf Coast Marlins and the Batavia Muckdogs; producing a combined 0–1 record with a 2.48 ERA and 13 strikeouts over 29 innings.

[7] Lee split the 2018 season between the Jupiter Hammerheads, the Jacksonville Jumbo Shrimp, and the New Orleans Baby Cakes, going a combined 8–3 with a 1.60 ERA and 63 strikeouts over 62 innings.

[10] He pitched in relief against the New York Mets on October 1, yielding one hit and recording his first strikeout in his major league debut.

He is the first pitcher in MLB history to make a first major league start in a World Series game.

[17][18] Lee began the 2022 season with Triple A Gwinnett, then was promoted to the major league roster on April 19, 2022.

On September 12, it was announced Lee would miss the remainder of the season after he was placed on the injured list with left shoulder inflammation.