Peptidoglycan glycosyltransferase

It transfers a disaccharide-peptide from a donor substrate to synthesize a glycan chain.

[1] This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases.

Other names in common use include PG-II, bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-, pentapeptide:peptidoglycan, N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase, penicillin binding protein (3 or 1B), and peptidoglycan transglycosylase.

Transpeptidases crosslink the carbohydrate chains to provide the framework for the cell wall.

[2] It catalyzes the chemical reaction The 2 substrates of this enzyme are whereas its 2 products are As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2BG1, 2UWX, and 2UWY.